Further analysis of the correlation between decreased METTL3 expression and disease using receiver operating characteristic (ROC) curves demonstrated that the area under the curve (AUC) for reduced endometrial METTL3 expression was 0.9136 (95% confidence interval (CI), 77.5% to 100%) in infertile patients with stage IV endometriosis (Fig. 1C), indicating downregulation of endometrial METTL3 could well distinguish infertile from fertile endometriosis patients. Here, METTL3 is linked to endometriosis.