Finally, there are many physiological factors that may influence plasma Aβ40 and Aβ42 levels: age (in our study we found inconsistent results: we only found a correlation with age and all plasma Aβ peptides in the validation cohort of patients with D-CAA and controls), renal and liver function (both affecting Aβ clearance), cerebrovascular diseases such as white matter hyperintensities and lacunes, coronary heart disease, body mass index, APOE ε4 status, and use of certain drugs such as acetylsalicylic acid, dipyridamole, antidiabetics, and anticoagulants [33–36]. Here, APOE is linked to cerebrovascular disorder.