Unique tumour features were identified that may augment the detection of MLH1 epimutation carriers, including genome-wide DNA methylation as depicted by Consensus Clusters, frequent somatic mutations in APC, KRAS codons 12&13, KMT2C and TCF7L2, a second somatic hit in MLH1 with monoallelic methylation [12], and APC promoter methylation. This evidence concerns the gene TCF7L2 and neoplasm.