BRAF and neoplasm: Sporadic MLH1 methylation is associated with an older age of CRC diagnosis, females and features of the serrated pathway of neoplasia [5] namely the co-existence of somatic BRAF p.V600E mutations and genome-wide hypermethylation of tumour suppressor genes, commonly referred to as high levels of CIMP (CpG Island Methylator Phenotype) [6].