Tumour hypermethylation (~ 50%) of the APC promoter region was present in all three MLH1 methylated EOCRCs similar to MLH1 epimutation CRCs (mean β = 0.57) and LS-CRCs (0.33) but higher than the MMR-proficient (0.19) and sporadic MLH1 methylated CRCs (0.16). Here, MLH1 is linked to neoplasm.