MLH1 and colorectal carcinoma: Similarly, both the CRCs from the MLH1: c.-11C > T VUS carriers showed MLH1 promoter hypermethylation (β = 0.43 and 0.39, respectively), while the CRC from the MLH1: c.-[28A > G; 7C > T] VUS carrier was only moderately increased (β = 0.14), compared with their respective normal mucosa samples (β = 0.06, 0.1 and 0.09, respectively) but not meeting our threshold of 0.2 (Additional file 2: Fig. S1).