A meta-study found that IL-6 decreased significantly in patients with acute schizophrenia and continued to decline in subsequent treatment for acute illness, IL-6, tnf-α and CRP had often been shown to be associated with psychiatric disorders, but this positive result was not found in our results, which may also be related to inconsistencies in patient inclusion criteria, detection timing, and detection methods, etc. [22]. Here, CRP is linked to psychiatric disorder.