Among four patients with positive anti-DGP and/or anti-tTG, only one had been previously diagnosed with CD and IgG subclass deficiency, one was under immunological care due to AN and lymphocyte T deficiency with a history of pyogenic infections, two were complaining of chronic diarrhoea (one of them had selective IgA deficiency and the other IgM deficiency). This evidence concerns the gene TGM2 and selective IgA deficiency disease.