Results demonstrated that MAPK3, TP53, VEGFA, PPARG, HIF1A, MMP9, FN1, JUN, ERBB2, NFKBIA were considered as top 10 targets; quercetin, stigmasterol, beta-sitosterol, baicalein, kaempferol, nobiletin, wogonin, naringenin, berberine, palmatine were most important anti-PD bioactive compounds. This evidence concerns the gene HIF1A and Parkinson disease.