Our findings reveal that Mn induced inflammatory neurotoxicity in the nigrostriatal region of the mouse brain of WT mice, which was exacerbated in G2019S mice characterized by increased dopaminergic dysfunction, motor deficits, and cognitive impairment, along with molecular alterations in LRRK2, tyrosine hydroxylase (TH), TNF-α, and IL-1β. Here, TH is linked to Cognitive impairment.