The present studies demonstrate that Mn exposure in WT mice induced motor deficits, cognitive impairment, and dopaminergic dysfunction in the nigrostriatal pathway with a concomitant increase in LRRK2 and TNF-α protein levels in the basal ganglia, which were further exacerbated in LRRK2 G2019S mice. The gene discussed is LRRK2; the disease is Cognitive impairment.