ACTA1 and idiopathic pulmonary fibrosis: Pre-treatment with Rev-erbα agonist GSK4112 (1 h) or GSK4112+TGFβ1 (1 h GSK4112 followed by TGFβ1 stimulation) significantly reduced TGFβ1-induced αSMA stress fibers in normal and IPF fibroblasts (Fig. 2C–D).