Among the various RNF213 variants, p.Ala4399Thr is the only variant reported to be associated with hemorrhage in patients with MMD, and Wu et al. reported that p.Ala4399Thr was associated with MMD (OR = 2.0), especially hemorrhagic MMD (OR = 2.8), in a Chinese population [8]. This evidence concerns the gene RNF213 and hemorrhage.