Therefore, regarding the boosting effects of ascariasis on the allergic response, we hypothesized that patients predisposed to asthma, with a strong pro-Th2 genetic background, parasitized at an early age, under regular deworming campaigns (followed by re-infections), and permanently exposed to mite allergens, have a stronger IgE response to allergens and more severe asthma clinical symptoms. The gene discussed is IGHE; the disease is infection.