Since HDM exposure is high and permanent in tropical environments and induces IgE sensitization at a very early age (Fig. 2), the cross-reactivity between several allergens from both sources (e.g., tropomyosins, glutathione S-transferases [GSTs], and other non-characterized components) may explain this potentiating effect of ascariasis [10]. Here, HPGDS is linked to ascariasis.