Among 75 unique mutated genes identified in metastatic tumors from the MET500 dataset, 9 of them are not present in any of the over 1000 cell lines from the Cancer Cell Line Encyclopedia, including ESR1, which is a metastasis driver and the 5th most altered gene preceded by TP53, PIK3CA, TTN and OBSCN. From the transcriptomic side, CCLE data reveals that MDA-MB-415 cells have the highest correlation with its tissue of origin and metastatic sites (liver and lymph node), and it is curiously the one that resembles Luminal A subtype the most [79]. Here, PIK3CA is linked to cancer.