Kang et al. exploited the promotional effect of basic fibroblast growth factor (bFGF) on the proliferative capacity of PDLSCs and synergized its action with that of BMP-2 on PDLSCs to enhance the osteogenic and mineralizing capacity of PDLSCs while effectively compensating for the inhibitory effect on the osteogenesis of PDLSCs [24].Therefore, periodontal stem cells form the basis for slowing the resorption of periodontal bone tissue, promoting bone tissue repair and regeneration, and improving the prognosis of patients with periodontitis. The gene discussed is BMP2; the disease is periodontitis.