Several mechanisms have been suggested for the observed association between exercise and reduced mortality risk in patients with cancer including the effect of exercise on (a) body fatness (whole‐body and visceral); (b) adipokines, such as leptin; (c) low‐grade inflammation which can be evaluated via serum C‐reactive protein (CRP); and (d) metabolic dysregulation which can be evaluated for example by serum insulin and insulin‐like growth factor‐1 (IGF‐1).10, 11, 12. The gene discussed is LEP; the disease is cancer.