The i10c CRE (Refseq i11iii) was first identified as a site of open chromatin in Caco2 cells, a colorectal adenocarcinoma cell line which expresses CFTR (Smith et al., 2000), however, it lacked enhancer activity in these cells (Phylactides et al., 2002); moreover, it was evident in skin fibroblasts that do not express CFTR (Yang et al., 2016). This evidence concerns the gene CFTR and colorectal adenocarcinoma.