HMGB1 and Schwartz-Jampel syndrome: TNF‐α is known to induce HMGB1 release from monocytes,20 and it is therefore possible that the extracellular levels of HMGB1 in SJS/TEN are due to TNF‐α‐induced release by both epidermal and immune cells, and are not only due to epidermal loss of expression.