However, the data presented herein suggest that epidermal HMGB1 expression may represent a highly sensitive biomarker of SJS/TEN and cellular HMGB1 translocation, a robust end‐point marker for assessing keratinocyte cell death (predominantly necroptosis) in SJS/TEN pathogenesis. This evidence concerns the gene HMGB1 and Schwartz-Jampel syndrome.