Analysis of the skin biopsies demonstrated that HMGB1 positive cells in pre‐blistered epidermis from SJS/TEN patients (91.3% ± 2.4, mean ± SE) were significantly lower than in healthy controls (99.5% ± 0.3, P = 0.047; Figure 4b). The gene discussed is HMGB1; the disease is toxic epidermal necrolysis.