Having establish a predominant role for necroptosis, in both our TNF‐α exposed and cell‐death inducible models, we next wanted to quantify HMGB1 release and assess the effect on it of etanercept (a TNF‐inhibitor used in the treatment of SJS/TEN4) in our in vitro model. The gene discussed is HMGB1; the disease is Schwartz-Jampel syndrome.