STAT3 regulates the cellular stress response, as well as apoptosis and wound-healing pathways [35] while Smad3 induces the expression of alpha-SMA, VEGF, and TGF-β1 in dermal fibroblasts and induces an increased chemotactic response, accelerating tissue repair in skin ulcers. This evidence concerns the gene TGFB1 and Skin ulcer.