MAPT and arteriolosclerosis: There also are many possible ways to operationalize each of the pathologic variables, including both the neurodegenerative (e.g., misfolded Aβ, Tau, α-Synuclein, and TDP-43 proteinopathies) and cerebrovascular pathologies (large infarcts, small infarcts, arteriolosclerosis, CAA, etc.).