SERPINE1 and diabetes mellitus: The associations between current smokers’ pack-years and diabetes-related outcomes (FG and HbA1c) were significantly mediated by GrimEAA, DNAm PAI-1 levels, DunedinPACE, and PhenoEAA (only HbA1c) (FDR < 0.05, Table 6 and Fig. 4).