Of note, in addition to both CD8 + TEM and CD8 + TEMRA cells exhibited excessive levels of GzmB, nearly all GzmB + CD8 + T cells were located in TEMRA cells of patients with SPMS, whereas there was no prominently increase of GzmB expression monitored in RRMS (Fig. 4A–C). The gene discussed is GZMB; the disease is secondary progressive multiple sclerosis.