The data showed that the distribution of breast cancer patients in the high expression group and the low expression group was significantly different in N stage (p = 0.003), pathologic stage (p = 0.032), ER status (p < 0.001), and PR status (p < 0.001), but there was no significant difference between HSPB1 expression and age, T stage, M stage, and HER2 status (All p > 0.05). The gene discussed is ESR1; the disease is breast carcinoma.