In addition, HSPB1 expression was increased in the breast cancer cell lines SK-BR-3, T47D, MDA-MB-231, MDA-MB-453, and BT474, especially in SK-BR-3 and MDA-MB-231 cells, compared with that in normal breast MCF10A cells (Fig. 1B). Here, HSPB1 is linked to breast carcinoma.