Treatment with mTOR inhibitor + CIS induced a minor decrease in IC50 concentration, while DZ-CIS caused a pronounced IC50 decrease to 0.3 μM for EVE + DZ-CIS (CDI = 0.028) and 0.19 μM for TEM + DZ-CIS (CDI = 0.003) (Fig. 3A and B; Table 2). This evidence concerns the gene MTOR and in situ carcinoma.