The above-mentioned six factors were forced into the multivariate linear regression model, and subsequently, 90-day mRS scores were independently correlated with serum MANF levels (beta, 0.018; 95% CI, 0.013–0.023; VIF = 1.984; t = 2.047; P = 0.043), NIHSS scores (beta, 0.138; 95% CI, 0.057–0.219; VIF = 2.948; t = 3.377; P = 0.001) and hematoma volumes (beta, 0.038; 95% CI, 0.004–0.072; VIF = 2.029; t = 2.228; P = 0.028). This evidence concerns the gene MANF and hematoma.