Combined with the currently identified role of GLuR in the process of cardiac and cerebral ischemia-hypoxia-reperfusion, the present study explored the relevant roles and mechanisms of GLuR-related crossover genes in the process of cardiac and cerebral ischemia and explores the role of GLuR-related crossover genes in the process of cardiac and cerebral ischemia through LASSO model construction. Here, GSR is linked to brain ischemia.