PRDX1 and pulmonary fibrosis: To confirm the roles of the PI3K/Akt and JNK/Smad signalling pathways in PRDX1-associated pulmonary fibrosis regulation, FMLF cells were pre-treated with the inhibitors of PI3K (LY294002) and JNK (SP600125) (hereafter, SP and LY, respectively).