Other notable pathways positively associated with LBH were inflammation cytokine-chemokine receptor signaling, consistent with a role of LBH in immunity [12] (Fig. 8); and angiogenesis/VEGF signaling, consistent with studies in GBM models showing that LBH induces VEGF-MEK-ERK signaling [18]. This evidence concerns the gene MAP2K7 and glioblastoma.