Here, we performed a systematic meta-analysis of LBH expression in a wide range of cancers, querying association with patient survival, DNA methylation status, and targetable signaling pathways, with immunohistochemical validation in patient samples and studies in multi-cancer cell lines, to explore the potential of LBH as a pan-cancer diagnostic marker and investigate potential mechanisms underlying the LBH dysregulation in cancer. The gene discussed is LBH; the disease is cancer.