LBH underexpression in cancer was further associated with de novo purine/pyrimidine synthesis, DNA replication, protein ubiquitin proteasome pathway, and neurodegenerative diseases characterized by protein defects (i.e., Parkinson, Huntington, Alzheimer disease), suggesting novel functions of LBH in RNA/DNA synthesis, protein turnover, and neurodegeneration (Fig. 8). Here, LBH is linked to early-onset autosomal dominant Alzheimer disease.