While expression of LBH, WNT, or Integrin pathway genes alone showed Hazard ratios of 1.80 (p = 0.015), 2.54 (p = 1.73E-04) or 3.77 (1.42E−06), respectively at a Confidence Interval of 95%, combinations of LBH with WNT or Integrin, or all three gene clusters combined increased predictive power linearly for the overall survival of patients to an HR of 7.72 (p = 2.30E−09) in COAD, an HR of 7.41 (p = 6.61E−14) in PAAD, and an HR of 5.95 (p = 1.62E−08) in STAD (Fig. 6C; and Table S6). The gene discussed is LBH; the disease is colon adenocarcinoma.