LBH and neoplasm: Prognostically significant LBH overexpression has also been reported in hepatocellular [15], gastric cancers [16, 17], and glioma [18, 19], where it promotes cell proliferation, invasion, angiogenesis, and tumor growth, in part through FAK/PI3K/AKT- and/or VEGF/ERK-dependent mechanisms [16, 18].