Notably, LBH upregulation in CRC, PAAD, ESCA, and STAD cancer lines coincided with both, increased β-catenin and TCF4 protein expression (Fig. 7C), as well as increased TOPFlash reporter activity, a measurement of β-catenin/TCF transcriptional activity (Fig. 7D). Here, HNF4A is linked to colorectal carcinoma.