Other common pathways were: Angiogenesis (8–9%), Cadherin signaling (7–9%), Gonadotropin-releasing hormone receptor pathway (7–10%), PDGF (6–8%) and EGF receptor (5–7%) signaling, Endothelin signaling (5–8%), and in some 3-cancer comparisons also Heterotrimeric G-protein signaling (5%), CCKR signaling (5%), the Alzheimer disease-presenilin pathway (4-5%), TGFβ (4-5%) and VEGF (4%) signaling, as well as T cell activation (4%) (Fig. 5; and Fig. S4). Here, GNRHR is linked to early-onset autosomal dominant Alzheimer disease.