In addition to the previous reported negative association between USP5 and the progression of BRCA13, BLCA27, CRC16, GBM22, LIHC17, melanoma28, NSCLC15,26, OV23 and PAAD20, our result first showed that USP5 may emerge as a novel biomarker for predicting the prognosis of ACC, LAML and MESO, especially MESO. Here, USP5 is linked to adrenal cortex carcinoma.