Previous studies had demonstrated that USP5 could regulate cancers by mediating epithelial–mesenchymal transition, such as, in LIHC by stabilizing Snail Family Transcriptional Repressor 217, in NSCLC by stabilizing Catenin Beta 125 and in BRCA by stabilizing Hypoxia-inducible factor 2α 13. Here, USP5 is linked to non-small cell lung carcinoma.