The results indicated that USP5 was expressed differently in 10 of 17 cancers for molecular subtypes, which showed the most increased level in the LumB subtype of BRCA (5 subtypes), HN-SNV subtype of COAD (4 subtypes), ESCC subtype of ESCA (5 subtypes), Classical subtype of HNSC (4 subtypes), C2b subtype of KIRP (4 subtypes), G-CIMP-low subtype of LGG (6 subtypes), primitive subtype of LUSC (4 subtypes), proliferative subtype of OV (4 subtypes), Kinasesignaling subtype of PCPG (4 subtypes) and CN_HIGH subtype of UCEC (4 subtypes) (Fig. 4A–J). Here, USP5 is linked to esophageal squamous cell carcinoma.