In addition, we further analyzed the association between the expression level of USP5 and disease-specific survival or progress-free interval of cancer patients, and we proved that on the whole, USP5 exhibited risk role in MESO and UVM for overall survival, disease-specific survival and progress-free interval, in LUAD and SKCM for overall survival and disease-specific survival and in COAD for disease-specific survival and progress-free interval. This evidence concerns the gene USP5 and colon adenocarcinoma.