In contrast, USP5 negative correlated with DNA repair in ALL (Acute Lymphoblastic Leukemia); with stemness in PC (Prostate cancer); with cell cycle in CRC (Colorectal cancer); with DNA repair, cell cycle and DNA damage in RB; with DNA repair, DNA damage, apoptosis, invasion, metastasis and quiescence in UM (Uveal Melanoma) (Fig. 11B–H). The gene discussed is RB1; the disease is uveal melanoma.