Considering the critical role of immune infiltration and immune regulation in the oncology progress, we first applied CIBERSORT, CIBERSORT-ABS, EPIC, MCPCOUNTER, QUANTISEQ, TIDE, TIMER and XCELL algorithms to explore the correlation between USP5 expression and the infiltration level of different immune and endothelial cells in pan-cancer of TCGA. Here, USP5 is linked to cancer.