NDP and Stroke: L6-F4-2 also improved stroke outcomes and BBB function in wild-type adult C57Bl/6J mice, thus enlarging potential benefits beyond Ndp/Tspan12 mutants or other WNT pathway-mutant hereditary retinopathies, to prevalent and disabling medical conditions in the general population such as cerebral infarction, as facilitated by our demonstration of successful intravitreal delivery.