L6-F4-2 also improved stroke outcomes and BBB function in wild-type adult C57Bl/6J mice, thus enlarging potential benefits beyond Ndp/Tspan12 mutants or other WNT pathway-mutant hereditary retinopathies, to prevalent and disabling medical conditions in the general population such as cerebral infarction, as facilitated by our demonstration of successful intravitreal delivery. Here, TSPAN12 is linked to Stroke.