Whereas we detected selective behavioral abnormalities including increased anxiety-like behavior in the open-field test in male Chd8 CKO mice and abnormal social behavior in female Chd8 CKO mice in this study, Chd8 heterozygous knockout mice manifest alterations in synaptic transmission, ASD-like behavioral phenotypes, and learning and memory deficits12–15,28. Here, CHD8 is linked to Anxiety.