RYR1 and centronuclear myopathy: The shape of the torso was suggestively associated with a QTL containing RYR1. Ryanodine receptor 1 gene mutations have been associated with malignant hyperthermia in many mammals including pigs51, dogs52 and horses53, but also with myopathies such as central core disease (CCD), Multiminicore Disease (MmD), Centronuclear myopathy (CNM) and axial hereditary myopathy54–56.