In this way, it was addressed in newly diagnosed women with BC categorized according to the clinical stage of the disease and molecular classification of the tumor, without pharmacological or surgical intervention, compared to control women (CTR): (1) plasma lipid profile [total cholesterol (TC), HDLc, apolipoprotein B (apoB) and triglycerides (TG)]; (2) the composition of isolated HDL in lipids, main species of oxysterols and apolipoprotein A-I (apoA-I); and (3) the ability of HDL to mediate cholesterol removal from macrophages. Here, APOA1 is linked to neoplasm.