Multivariate analysis identified male sex (HR = 4.84; 95% CI 1.83–12.8, p = 0.001), FIB-4 index at EOT (HR = 1.09; 95% CI 1.01–1.18, p = 0.028), and the AFP level at EOT (HR = 1.13; 95% CI 1.06–1.19, p < 0.001) as independent factors that contributed to the development of HCC (Table S2). Here, AFP is linked to hepatocellular carcinoma.