AFP and hepatocellular carcinoma: Multivariate analysis identified DM (HR = 3.95; 95% CI 1.19–10.7, p = 0.023), FIB-4 index at SVR12 (HR = 1.11; 95% CI 1.04–1.18, p < 0.001), and the AFP level (HR = 1.05; 95% CI 1.00–1.11, p = 0.035) at SVR12 as independent factors that contributed to the development of HCC (Table 2).