Notably, cytokines from the entire first components of variance for serum (Group 1), β-NGF, TNFα, G-CSF, IL-1α, IL-2, IL-4, IL-8, IL-3, MIP-1β, IL-9, IL-17A, and IL-7, are all present in the first component of variance for brain cytokines, again confirming the prominence of the NFκB pathway in the etiology of bvFTD. This evidence concerns the gene IL1A and behavioral variant of frontotemporal dementia.