The significance of the NFκB pathway in the pathogenesis of FTD was further confirmed by results emerged from the principal component analyses, in which cytokines from the first component of variance for brain cytokines, group 1 (Table 4), are all related to the NFκB signaling pathway, either as NFκB regulators and/or downstream effectors of the NFκB pathway. The gene discussed is NFKB1; the disease is frontotemporal dementia.