Notably, cytokines from the entire first components of variance for serum (Group 1), β-NGF, TNFα, G-CSF, IL-1α, IL-2, IL-4, IL-8, IL-3, MIP-1β, IL-9, IL-17A, and IL-7, are all present in the first component of variance for brain cytokines, again confirming the prominence of the NFκB pathway in the etiology of bvFTD. The gene discussed is TNF; the disease is behavioral variant of frontotemporal dementia.