Differently, the Spike-specific CD8+ T cell immune response in N-immunized mice was elicited at lower levels (Kruskal–Wallis Test followed by Dunn’s Multiple Comparisons Test, Nefmut/N-vaccinees vs sham mice, at day 6: p < 0.05), in the presence of an N-specific immunity not diminished compared to pre-infection levels (Fig. 8b). The gene discussed is CD8A; the disease is infection.