Focusing on TET2, we show that neutrophils constitute a high-frequent TET2-mutant cell subset among the hematopoietic tree in the different tissues analyzed (BM, blood, and lung), and we provide valuable insights into the cellular heterogeneity that individuals with TET2-derived CH likely display, and how we can improve diagnostic strategies based on such differences. Here, TET2 is linked to cyclic hematopoiesis.