Interestingly, overexpression of MEG3 in both the p53 WT MOLM‐13 and p53 mutant U937 AML cell lines was found to significantly reduce cell proliferation and induce G0/G1 cell cycle arrest and apoptosis, suggesting that MEG3 can function as a tumor suppressor in a p53‐independent pathway. Here, TP53 is linked to acute myeloid leukemia.