In a 2018 study, Gao et al. found that knockdown of HOTAIR in AML reduced the frequency and self‐renewal capabilities of leukemic stem cells (LSCs) via promoting EZH2‐mediated tri‐methylation of Lys 27 of histone (H3K27me3) of the p15 promoter. The gene discussed is EZH2; the disease is acute myeloid leukemia.