However, we can identify five top genes at 22q11.2 associated with BMI (YDJC, CCDC116, PPIL2, THAP7, UBE2L3), primarily located outside the canonical CNV region (LCR D-E), three with bipolar disorder (TMEM191B, TUBA8, PPIL2), six with ASD (CLTCL1, AC004471. This evidence concerns the gene UBE2L3 and bipolar disorder.