In two cases–bipolar disorder at 16p11.2 and bipolar disorder at 22q11.2 –one gene stood out as a disproportionate contributor to pairs (although in 16p11.2 there was a noncoding gene just on the threshold ~2.5 SD), but in both regions the disproportionate contributor was also a top single gene association (INO80E and PPIL2 respectively). The gene discussed is INO80E; the disease is bipolar disorder.