The comorbidities of COVID-19-related ARDS were less chronic renal failure (2 [4.0%] vs. 10 [20.0%], p = 0.014), and immunocompromised status (0 [0.0%] vs. 10 [20.0%], p = 0.001), and laboratory data presenting higher neutrophil (88.5 [84.2–92.8] vs. 80.0 [54.0–89.4] %, p<0.001) and lower C-reactive protein (CRP) (9.4 [3.8–13.2] vs. 13.8 [8.4–21.9] mg/dL, p = 0.004), and creatinine (0.9 [0.7–1.1] vs. 1.3 [0.9–2.4], p = 0.001) levels. This evidence concerns the gene CRP and acute respiratory distress syndrome.