CASP1 and Increased total eosinophil count: NLRP3 mediated inflammasome formation activates caspase-1 mediated programmed cell death and is responsible for not only increased neutrophil infiltration but the upregulation of chemokines and proinflammatory cytokines via this pathway also leads to eosinophilia [40] as well as increased housing of macrophages, B cells and T cells in lungs.