Furthermore, gene mutations such as CCBE1, FAT4, GJC2, VEGFC, PTPN14, GATA2, HGF, and PIEZO1 could induce generalized lymphatic dysplasia, inherited lymphedema type 1C and 1D, lymphedema-choanal atresia, Emberger, and lymphedema-lymphangiectasia, and hereditary lymphedema III, respectively. Here, GJC2 is linked to lymphedema.