Posttranslational modifications such as sumoylation, DNA methylation, and acetylation are evident in the tail region of these histone proteins.170 These alterations are associated with the formation of H3K4me2 and H3K4me3 across the gene region of the promoter, subsequently causing alterations in oncoprotein expression to foster cancers.171,172 These histone alterations are yet to be explored in the pathophysiology as these modifications may play a prominent role in the DNA-mediated cellular processes in BCRL.173. The gene discussed is H2BC12L; the disease is cancer.