CD4 and neoplasm: A total of five CD4+ and four CD8+ T cell clusters were identified in tumor and normal tissues, including CD8+ intraepithelial lymphocytes (CD8+ IELs), effector memory CD8+ T cells (CD8+ Tem), recently activated effector memory or effector CD8+ T cells (CD8+ Temra/Teff), exhausted CD8+ T cells (CD8+ Tex), central memory CD4+ T cells (CD4+ Tcm) and naive CD4+ T cells (CD4+ Tn), tissue-resident memory CD4+ T (CD4+ Trm) cells, TH1-like cells, Treg cells, and T cycling cells (Figure 5—figure supplement 1A, B).