CD8A and hepatocellular carcinoma: In conclusion, the expression level of TICRR was significantly positively correlated with infiltrating levels of CD8 + T-cells (r = − 0.187, p = 0.0003), T helper cells (r = 0.313, p = 6.3821E-10), Cytotoxic cells (r = − 0.262, p = 2.7209E-07) and neutrophils (r = − 0.344, p = 8.009E-12) in HCC (Fig. 5A).