Through the TICRR Gene co-expression networks and PPI network analysis of TICRR in HCC, it was found that the Topoisomerase (dna) II-binding protein1 (TOPBP1), Cell division control protein 45homolog (CDC45), Mdm2- binding protein (MTBP), Minichromosome maintenance complex component 2 (MCM2), Protein MCM10 homolog (MCM10), Protein DBF4 homolog (DBF4), Serine/threonine-protein kinase Chk1 (CHEK1), DNA replication factor Cdt1 (CDT1), Cell division control protein 6 homolog (CDC6), and Bromodomain-containing protein 2 (BRD2) were recognized as the top ten correlated genes with TICRR in HCC. Here, TOPBP1 is linked to hepatocellular carcinoma.