In this study, we comprehensively analyzed the differences of TICRR expression in diverse cancer types including HCC, clinicopathological relevance, diagnostic and prognostic value, DNA methylation level, and the underlying functional mechanisms of TICRR gene in HCC using The Cancer Genome Atlas (TCGA), Kaplan–Meier Plotter, TIMER 2.0, GEO, and various public databases. The gene discussed is TICRR; the disease is hepatocellular carcinoma.