The analysis showed that the expression level of TICRR was noticeably correlated with B-cell biomarkers (CD19 and CD79A), CD8 + T-cell biomarkers (CD8A and CD8B), T-cell biomarkers (CD3D, CD3E, and CD2), other T-cell subsets (Th1 and Th2), Monocyte biomarkers (CD86 and CSF1R), TAM biomarkers (CD68 and IL10), M1 macrophage biomarkers (IRF5), neutrophil biomarkers (ITGAM and CCR7), natural killer cell biomarkers ( B3GAT1 and CD7), dendritic cell biomarkers (CD1C), and exhausted T-cells biomarkers (PDCD1, HAVCR2, TOX, NRP1, LAG3, SLAMF6, and TIGIT) in HCC (P < 0.05, Table 2). The gene discussed is TIGIT; the disease is hepatocellular carcinoma.