Other HCC biomarkers, such as α-L-fucosidase (AFU), fucosylated fraction of AFP (AFP-L3) (Chalasani et al. 2021), carbohydrate antigen 199 (CA199), and carcinoembryonic antigen (CEA), have also been reported to have some limitations in the diagnosis of HCC. The gene discussed is AFP; the disease is hepatocellular carcinoma.