Recent studies demonstrated that colocalization was also observed for GBP2 (IFN-induced protein) and Iba1 (microglia marker) through double immunofluorescence analysis in the brain cortex in a rat model of traumatic brain injury, suggesting that GBP2 might play a vital role in microglia activation process following brain damage (Miao et al. 2017). Here, AIF1 is linked to brain injury.