Isorhamnetin is a natural antioxidant that hinders the EMT process and endoplasmic reticulum stress by modulating the PERK signaling pathway to reduce bleomycin-induced pulmonary fibrosis in mice.[20,21] DA is an abietane-type diterpene ester derived from the roots of Salvia miltiorrhiza. This evidence concerns the gene EIF2AK3 and pulmonary fibrosis.