As in our data, PLA2R1 was downregulated in a number of other cancers and showed tumor suppressive activity.[29] PLA2R1 was a 180 kDa transmembrane glycoprotein expressed in human foot cells, which was widely studied and reported in the membranous nephropathy,[30] but the relevant research of PLA2R1 in thyroid cancer remains unclear. This evidence concerns the gene PLA2R1 and cancer.