On the other hand, SNAI1 also acted as a transcriptional activator to increase other epithelial-mesenchymal transformation transcription factors.[26] It has been reported that SNAI1 expression suppressed cellular senescence in a variety of cancer cells and delayed the progression and metastasis of cancer.[27] SNAI1 has also been confirmed to be involved in the migration and invasion of thyroid cancer.[28] SNAI1 with multiple functions was worthy of further discussion and research. This evidence concerns the gene SNAI1 and thyroid cancer.