The role for tp53 in self-renewal and metastasis of kRASG12D-induced ERMS tumors was assessed using cell transplantation assays and revealed that tp53 loss does not change the overall frequency of ERMS self-renewing cancer stem cells compared to tumors expressing wild-type tp53 (Ignatius et al., 2018). Here, TP53 is linked to embryonal rhabdomyosarcoma.