Finally, by comparing our zebrafish brain tumors with medulloblastoma gene signatures outlined in Pomeroy et al., and Kool et al., we found that our brain tumors expressing tp53-/- + TP53P153Δ were consistent with the sonic hedgehog subgroup of medulloblastomas (Figure 5H, Figure 5—figure supplement 4; Kool et al., 2014; Pomeroy et al., 2002). This evidence concerns the gene TP53 and medulloblastoma.