Altogether, our data reveal that both the TP53P153Δand TP53Y220C mutations predispose to head ERMS tumors in zebrafish but differ in their effects on tumor initiation, apoptosis and expression of p53 target genes noxa, baxa, bbc3 and gadd45a (SupplementarySupplementary file 1 File 1). Here, TP53 is linked to embryonal rhabdomyosarcoma.