The tp53-/- complete loss-of-function mutant zebrafish line (Ignatius et al., 2018) spontaneously forms a broader tumor spectrum than tp53M214K/M214K, including MPNSTs, angiosarcomas, NK-cell leukemias, as well as germ cell tumors (Berghmans et al., 2005; Ignatius et al., 2018), suggesting the possibility of differential effects in RAS-driven ERMS. This evidence concerns the gene TP53 and aggressive NK-cell leukemia.