Notably, CCR7 has been shown to play a critical role in directing chemotaxis of post-positive selection thymocytes toward the medulla, where CCR7 ligands are expressed, enhancing thymocyte accumulation within the medulla, enforcing negative selection to TRAs, and averting autoimmunity (Ehrlich et al., 2009; Kozai et al., 2017; Kurobe et al., 2006; Nitta et al., 2009; Ueno et al., 2004). Here, CCR7 is linked to Autoimmunity.