PLOD1 and Cataplexy: No studies have directly explored how the loss of AMY OX receptor signaling alters liability for cataplexy while animals are exposed to wheel-running, chocolate, predator odor, social stress, etc. While the model we show involves Orx-LH and AMY both converging on neurons that promote muscle tone, it will be beneficial to also understand how Orx-LH neurons may affect emotional processing in the AMY directly, since emotions can trigger cataplexy.