ANGPTL3 and Netherton syndrome: In addition, longitudinal follow-up was conducted on four NS patients at different time points, and the changes in serum ANGPTL3 and urinary ANGPTL3/Cre levels detected showed almost the same trend as the changes in urinary protein, which suggesting that ANGPTL3 may reflect the disease activity of NS, however, further studies are still needed (Figures 4A–D).