And revealed that ANGPTL3 level in serum and urine was correlated with the degree of proteinuria and was a valuable marker to assess the disease severity of NS, which showed a satisfactory performance for NS and provided some theoretical basis for the use of anti-ANGPTL3 drugs or antibodies for NS patients in the future clinical translation stage and further exploration of the role of ANGPTL3 may shed light on the treatment of NS. The gene discussed is ANGPTL3; the disease is Netherton syndrome.