However, few studies have concentrated on the role of ANGPTL3 in NS, and we first discovery that ANGPTL3 was upregulated in minimal change nephrotic syndrome (MCNS) kidney tissues, which clarified the importance of ANGPTL3 in the pathogenesis of podocyte injury and nephropathy proteinuria (15). The gene discussed is ANGPTL3; the disease is Netherton syndrome.