In addition, MMP-2, MMP-9, and MMP-14 cleave the TGF-β-binding protein 1 (LTBP-1) present in the ECM, leading to the release of ECM bound TGF-β (Dallas et al., 2002; Tatti et al., 2008), which helps establish a tumor-supportive environment. This evidence concerns the gene TGFB1 and neoplasm.