Besides, CDKN2A, a cell cycle negative regulator, is involved in the progression of dysregulated epithelial cell senescence and triggering the activation of fibroblasts and myofibroblasts in IPF patients (27, 28).Therefore, CRGs may attend to the progression of IPF, but more studies are needed. Here, CDKN2A is linked to idiopathic pulmonary fibrosis.