It also has been widely reported that NF-κB is one of the essential pathways in the progression of IPF, and blockade of NF-κB prevented lung fibroblast-mediated IL-6, IL-8, and CXCL6 cytokine secretion as well as accumulation of profibrotic factors (40). This evidence concerns the gene NFKB1 and idiopathic pulmonary fibrosis.